Safety Studies Completed

A white paper presenting a biocompatibility safety evaluation for MeliMed Bend. Bend has been evaluated for biological safety as an implantable barrier membrane used for wound management.  This evaluation includes multiple in vitro and in vivo ISO 10993 standard testing such as chemical characterization, toxicological risk assessment, cytotoxicity, sensitization, irritation, acute systemic toxicity, subchronic toxicity, pyrogenicity, and implantation.  The results of these biocompatibility tests demonstrated that there are no biocompatibility concerns with MeliMed Bend and that it is safe for use in veterinary applications.         

Wound Care Performance Study Completed

COMING SOON: A white paper presenting an in vivo wound healing study in a porcine model that evaluated the regenerative potential of MeliMed Bend. Full thickness wounds were created and were either treated with Bend or non-treated. Digital images to assess wound closure were captured on average every 3 days and, after 14 and 21 days, samples were histologically analyzed. These results indicate that Bend supports the wound healing process and helps serve as a barrier to protect the wound during healing.

Dental Performance Study Completed

COMING SOON: A white paper presenting an in vivo study that evaluated the regenerative potential of MeliMed Bend. This study was an anatomically relevant porcine socket preservation model used to evaluate regenerative potential of exposed and non-exposed Bend for use in dental surgeries to facilitate regeneration of the overlying gingiva while supporting underlying bone growth. The results of this in vivo study demonstrate that Bend promotes full epithelialization of the gingiva by 4 weeks (faster than the comparative membrane control) and protects the underlying bone by facilitating normal bone growth. These results support the use of MeliMed Bend as an absorbable regenerative membrane for veterinary applications.

Degradation Performance Study Completed

COMING SOON: A white paper presenting an in vivo study that evaluated the degradation profile of MeliMed Bend. This study was a rabbit muscle implantation model, as part of ISO standard (10993-6) biocompatibility evaluation, to evaluate the degradation profile of Bend. The results of this in vivo study demonstrate that Bend resorbs within 4-10 weeks. These results support the use of MeliMed Bend as an absorbable regenerative membrane for veterinary applications.