MXTECH

Developed in partnership with the University of Memphis, we are the inventors of MXTECH – a patent-pending, innovative material manufactured from a collagen derivative, hydroxyapatite (HAp), and Manuka honey. The collagen derivative mimics the extracellular matrix of soft tissue and provides necessary support of tissue regeneration [1]. The HAp promotes wound healing while providing enhanced mechanical scaffold structure [2-7]. The Manuka honey has a low pH and high osmolarity, and increases fibroblast activity while absorbing moisture to provide a hospitable moist wound healing environment [8-14]. We are the first to combine these materials and features into a single technology, creating MXTECH - one of the most advanced and supportive biomaterials. Our products provide a wound healing environment unlike any available in the market today. The first product to be manufactured with MXTECH is MeliMed Bend, our absorbable regenerative membrane for use in veterinary dentistry.

  1. Grover, C.N., R.E. Cameron, and S.M. Best, Investigating the morphological, mechanical and degradation properties of scaffolds comprising collagen, gelatin and elastin for use in soft tissue engineering. J Mech Behav Biomed Mater, 2012. 10: p. 62-74.

  2. Okabayashi, R., et al., Efficacy of polarized hydroxyapatite and silk fibroin composite dressing gel on epidermal recovery from full-thickness skin wounds. J Biomed Mater Res B Appl Biomater, 2009. 90(2): p. 641-6.

  3. Majeed, A.A. and R.A. Al Naimi, Role of Hydroxyapatite in Healing of Experimentally Induced Cutaneous Wound in Rabbits. Journal of Veterinary Sciences, 2012. 5(1): p. 74-81.

  4. Kawai, K., et al., Calcium-based nanoparticles accelerate skin wound healing. PLoS One, 2011. 6(11): p. e27106.

  5. Weilin, Y., et al., Design of a novel wound dressing consisting of alginate hydrogel and simvastatin-incorporated mesoporous hydroxyapatite microspheres for cutaneous wound healing. RSC Advances, 2016(106): p. 104375-104387.

  6. Tommila, M., et al., Bioactive glass-derived hydroxyapatite-coating promotes granulation tissue growth in subcutaneous cellulose implants in rats. Acta Biomater, 2008. 4(2): p. 354-61.

  7. Rodriguez, I.A., et al., In vitro characterization of MG-63 osteoblast-like cells cultured on organic-inorganic lyophilized gelatin sponges for early bone healing. J Biomed Mater Res A, 2016. 104(8): p. 2011-9.

  8. Lusby, P.E., A. Coombes, and J.M. Wilkinson, Honey: a potent agent for wound healing? J Wound Ostomy Continence Nurs, 2002. 29(6): p. 295-300.

  9. Al-Waili, N., K. Salom, and A.A. Al-Ghamdi, Honey for wound healing, ulcers, and burns; data supporting its use in clinical practice. ScientificWorldJournal, 2011. 11: p. 766-87.

  10. Mavric, E., et al., Identification and quantification of methylglyoxal as the dominant antibacterial constituent of Manuka (Leptospermum scoparium) honeys from New Zealand. Mol Nutr Food Res, 2008. 52(4): p. 483-9.

  11. Phillips, P.L., et al., Biofilms Made Easy. Wound International, 2010. 1(3).

  12. Bergman, A., et al., Acceleration of wound healing by topical application of honey. An animal model. Am J Surg, 1983. 145(3): p. 374-6.

  13. Eteraf-Oskouei, T. and M. Najafi, Traditional and modern uses of natural honey in human diseases: a review. Iran J Basic Med Sci, 2013. 16(6): p. 731-42.

  14. Larjava, H., et al., Exploring scarless healing of oral soft tissues. J Can Dent Assoc, 2011. 77: p. b18.